Windowed

If enabled, the Windowed option will allow the game to render in a non-fullscreen window that you can freely move around and set to various resolutions. When this option and the Dedicated Fullscreen option are disabled, the game is running in a borderless fullscreen window.
[Options > Graphics > Advanced > Windowed]

Dedicated Fullscreen

If enabled, the Dedicated Fullscreen will enable Hardware Switching mode for your GPU. Essentially, this will make Alt-Tabbing from the game rougher, but sets the game to fully utilize the GPU while in-focus. This rarely provides any performance benefit for Muffed, so is disabled by default. When this option and the Windowed option are disabled, the game is running in a borderless fullscreen window.
[Options > Graphics > Advanced > Dedicated Fullscreen]

Resolution

Using this menu you can set the resolution that you'd like the game to run in. If the Windowed option is not enabled, and you set any resolution other than your monitor's current OS-set resolution, the Dedicated Fullscreen option will auto-enable since the game won't be able to run in borderless fullscreen at a non-default resolution. Muffed will run at any resolution, but should not be run at any resolution smaller than about 1024x768, or else some elements may render off-screen.
[Options > Graphics > Advanced > Resolution]

VSync

Enabling the vysnc option will force the game to run at the same FPS as your monitor's refresh rate. In most cases, this will cap the FPS to 60.
[Options > Graphics > Advanced > VSync]

Antialiasing

Antialiasing is a post-processing feature. When enabled, this will allow your GPU to process the rendered game and will usually make lines appear smoother. However, because this usually causes a pretty serious performance drop, it is disabled by default.
[Options > Graphics > Advanced > Antialiasing]